Adverse Effects of Desmopressin Sublingual

Researchers at the Institute of Pediatrics, Catholic University Medical School, Rome, Italy reported their observation of side effects of a new form of the drug DDAVP in the Turkish Journal of Urology.

DDAVP (Desmopressin) is sometimes used as a treatment for bedwetting. However, many pediatricians don’t rely on it as a first line therapy because of its potentially severe side effects. Most parents also don’t want their child to take the drug because it works by preventing the formation of urine, which is one of the ways the body eliminates toxins. In addition, many children resume wetting the bed when DDAVP therapy is discontinued.

This studied observed the rate of severe side effects (adverse reactions) in 237 children using a new form of DDAVP that melts under the tongue. The researchers state that the new form makes the drug more available to the body and thus can be prescribed in lower doses.

They found that there were fewer severe side effects overall with the most common being psycho-behavioral and the second most common being neurological. Examples of these adverse reactions were irritability, aggression, poor attention and headache. Lesser seen were abdominal pain, nausea, vomiting, difficulty falling asleep, and fatigue.

For parents who prefer a natural non-drug approach to ending bedwetting instead of waiting to outgrow it, an educational nonprofit such as Dry Kid Academy may be the right path. Using  educational principles and motivational methods, parents and children work together as a family to help their child wake up Dry every morning.

For more information about the new form of medication ask your chikd’s pediatrician. To find out if your child is eligible for Dry Kid Academy answer a few questions in the brief survey at


Negative Effects of Bedwetting are found Worldwide.

Effects ofBedwetting
Effects of Bedwetting and Parents’ Options

Doctors from around the world agree that nighttime bedwetting (medical term: nocturnal enuresis) can have negative effects on the child. In an article published in a Korean Medical Association Journal (1) Korean authors reviewed the scientific literature of enuretic (bedwetting) children from several regions of the world including Turkey, Great Britain, and Korea. They affirm that “Children with enuresis may have lower self-esteem and lower quality of life,” and that bedwetting “may affect negatively the psychosocial development of children.”

However, the main purpose of the article was to promote prescription drugs as a primary treatment. Interestingly, most U.S. doctors don’t like to prescribe for bedwetting as we discussed in a previous post because the drug options have potentially serious side effects. The medications the authors write about are Desmopressin, (also known as DDAVP), anticholinergics, and Imipramine. These are briefly reviewed below.

Desmopressin acts to prevent the child’s body from making urine. This medication has worked to prevent bedwetting. Often it works while it being used and many children return to bedwetting once the medication is stopped. The logic behind this treatment is, if the body is making too much urine, just stop urine production. However, because we need to produce urine to eliminate waste Desmopressin would only be prescribed at night, effectively delaying the natural waste elimination process. Many parents don’t like the idea of preventing waste elimination.

Anticholinergics are a broad category of medications used to treat a wide variety of conditions including Parkinson’s Disease (e.g. Cogentin) and psychiatric disorders (e.g. Thorazine).  Anticholinergics work by blocking the neurotransmitter called acetlycholine which is necessary for muscle contraction. The logic behind this treatment for bedwetting is to prevent the bladder (a muscle) from contracting, acting as an antispasmodic medicine. If a child is wetting due to bladder spasms, he or she will likely also have daytime wetting.

Imiprimine is an antidepressent used to treat depression. Even the Korean authors admit that it “has serious and lethal cardiotoxic effect,” and do not recommend it for childhood bedwetting. The logic behind this medication is probably closest to the actual cause of most cases of bedwetting, deep sleep. Imiprimine reduces the amount of time a person spends in deep sleep. However, the potential danger outweighs the potential benefits of this medication.

It’s always a good idea to check with your child’s pediatrician to rule out a medical cause of bedwetting but in otherwise healthy children, the cause is usually deep sleep. For these cases there is an alternative way end bedwetting. Most doctors now agree that education with an individualized training program is the best way for a child to learn how to wake up dry. For years, instead of resorting to potentially dangerous prescription medications, doctors would encourage parents to wait until the child outgrows bedwetting. This wasn’t entirely bad advice because most kids do outgrow it. In fact, only 1% continue wetting into adulthood. But the question is, when will they outgrow it? Will your child be in the 1%? How how long is too long to wait?

Most children learn to be dry at night by around age 3 but wets nights occurring to age 4 are not uncommon. Boys tend to take longer than girls to get dry at night and boys are more likely to continue wetting beyond 5 years old. Your child should be dry at night by the time he or she starts kindergarten. This is also likely the time when they’ll realize that bedwetting is not normal. The sooner it is corrected after your child has this awareness, the better. Thus, the time to intervene is when your child is aware that it’s not usual, is wetting on a regular basis (several nights), and is at least 5 years old.

Dry Kid Academy was founded in 2008. It is an in-home education and training program. No office visit. No clinic settings. Each family receives unlimited support and guidance until dryness is achieved and beyond if necessary.

To learn if Dry Kid Academy is right for your child answer a few questions here


Article Reference: (1)

A Literally Shocking Experiment On Bedwetting!!

It’s not surprising that this experiment was conducted in Denmark because Danish researchers are no strangers to conducting bizarre, even unspeakable scientific studies on its citizens. For instance, in 2015 BBC News reporter Ellen Otzen (1) reported on a 1950s Danish experiment designed to create “model citizens.” Scientists extracted 21 children from their families in Greenland and raised them  in Danish foster homes! The reporter interviewed some of the subjects, who are now in their 70s. She reports on the psychological damage the experiment caused.

A recent experiment published in the Journal of Urology (2) on Danish children studied a method to cure nighttime bedwetting with transcutaneous electric nerve stimulation (TENS). Here is the conclusion researchers in Denmark made, verbatim, “The present study demonstrates no anti-enuretic effect of transcutaneous electrical nerve stimulation in children with monosymptomatic nocturnal enuresis without nocturnal polyuria. Nocturnal urine production and bladder capacity remained unchanged during and after treatment with transcutaneous electrical nerve stimulation.” In other words, the children who participated in the experiment had no other problems except bedwetting. They also didn’t have multiple episodes of wetting at night. And the researchers concluded that using TENS did not stop any of the children from wetting the bed.

To be fair to Danish scientists, TENS has been evaluated as a possible treatment for many conditions including diabetic nerve pain (3) and has been studied as a camparison treatment for other conditions, including acupuncture (4). TENS is not a dangerous treatment. In fact, many studies show that is doesn’t really have an effect either way on conditions or other treatments. But it does have some therapeutic value. TENS is simply a painless electric current applied to the skin and it is commonly used by healthcare practitioners for the treatment of pain (5).

In another study of bedwetting published in the Pediatric Journal of Urology (6), researchers studied children who wet the bed and had other symptoms as well.  TENS was applied to the base of the spine 3 times a week for 6 weeks and researchers reported that bedwetting resolved in less than half (42%) of the cases. They concluded that TENS “can be an effective treatment for NMNE, but about a third of patients will need another kind of treatment.”

The best and most effective solutions to resolve childhood bedwetting are realized through a combination of education and behavior modification (7). It’s important that parents become educated on what to do and many times what to STOP doing to try to correct bedwetting. It’s also critical to objectively understand from the child’s perspective and to provide an individualized behavioral training plan that will work for their child. Every child is different and what works for one child may not work for another. This is why many parents find that bedwetting alarms are ineffective. Finally, it’s paramount to immediately respond to and take corrective actions during training. Knowing what to do at each stage of correction will help ensure a permanent end to the bedwetting. There’s an old joke about the man who brought his car to the mechanic. The mechanic lifted the hood and fixed the car with one swing of a hammer and charged the man $600. The man complained, but all you did was hit it with a hammer! And the mechanic replied, “Yes, it’s $1 for hitting it with the hammer and $599 for knowing where to hit.” He never had a problem with his car again.

Bedwetting can be tricky to fix sometimes. It’s easy to get frustrated and knowing exactly what to do and when to do it isn’t always clear. This is why Dry Kid Academy uses a research-based approach to correcting bedwetting that works for most kids in about 90 days but if you’re child takes a little longer, it’s okay because Dry Kid Academy stays with you until dryness is achieved.









7. WebMD Medical Reference Reviewed by Amita Shroff, MD on March 22, 2016

Could a Cure for Bedwetting be found in the Gut?

It’s no secret that bedwetting is a sleep disorder but the research has been unclear as to whether or not it’s inherited. The thought has been that bedwetting (a.k.a. primary nocturnal enuresis) most likely is inherited because it tends to run in families.  Well now comes along new research about the role of prebiotics.

If you haven’t heard the word “probiotics” then you most likely don’t know what “prebiotics” are. Prebiotics occur naturally in some healthy foods like  apples, peas, asparagus and many other fiber-rich foods and provide an environment for probiotics to grow. Probiotics nourish the healthy bacteria in your gut and are the center of a new ideology for curing many diseases from allergies to cancer.

What’s s interesting and relevant to bedwetting is a January 2017 study (1) showing that prebiotics improved R.E.M. (rapid eye movement) sleep in lab animals.

One of the hallmarks of the type of bedwetting that DryKid clients have is deep sleep. Deep sleep is non-R.E.M. sleep and serves the purpose of restoring the body during sleep. R.E.M. sleep restores the mind and is lacking in enuretic children.

It’s been long known that children should eat a well balanced diet. This research provides evidence that not only does eating right help children grow up to be strong and healthy adults but it also normalizes  sleep and may play a role in correcting bedwetting





How is constipation related to bedwetting?

Most kids who wet the bed are deep sleepers. They just can’t wake up! These are the kids that has been helping since 2008. DryKid Training is almost 100% effective in about 90 days. This is not a guarantee. No one can legitimately guarantee results. But this is the effectiveness rate we’ve been experiencing and we’re proud of it.

Occasionally, we come across a kid who has constipation and this is important. Not only can constipation be related to bedwetting but it can have long term health consequences as well. The relationships to constipation is simply due to the location of the lower bowel and the bladder. The lower part of the large intestine is right behind the bladder. Therefore, if this intestinal tube is full it can press on the bladder and cause unwanted urination. Typically, if this is the cause of bedwetting the child will also experience wetting during the day. This is the reason we ask if your child is dry during the day on our Can DryKid Training Help? questionnaire.

If the pressure on the bladder by a full intestine is causing bedwetting then we advise parents to take steps to remedy the constipation first. Some parents do this by adding fiber to the child’s diet but as a caution, this can make the constipation worse because for fiber to be effective, it must be consumed with large amounts of water (and this is the most common mistake parents make in attempting to treat bedwetting – they restrict liquids – which doesn’t work!).

So, if your child suffers from both constipation and bedwetting with wetting during the day, our advice is to seek the guidance of your child’s doctor who may recommend dietary changes, stool softeners and/or other natural remedies that are effective in restoring normal bowel movements.

If your still not certain if your child would benefit from DryKid Training, click on the link in this post. We will review your answers and let you know. You might like to also join our DryKid Training page on Facebook @drykidtraining

Written and contributed by Dr. Richard Parenti, Founder of and Dry Kid Academy, Inc. (an educational nonprofit organization dedicated to helping families with a child who wets the bed at night).

Even doctors don’t like prescribing for bedwetting…

One of the drugs that doctors can (but don’t like to) prescribe for bedwetting is Amitriptyline. Don’t blame your M.D. for not wanting to give your child this drug. Take a look at the list of the side effects for this antidepressant below. If you still want to know more, click the picture.Amitriptyline-pic.10mg-tablets-on-a-white-background

Testicular swelling

Interference with sexual function

Elevation or lowering of blood sugar levels


Blurred vision

Suicidal behaviors


Urinary retention

Libido fluctuations

Disturbed concentration

Increased appetite

Weight gain


Skin rashes

Sensitivity to sunlight

Breast enlargement

Heart problems

Ringing in ears

Bone marrow depression


Lack of sleep




Abnormal milk discharge from the breast

Dry mouth


Confusional states


Itchy skin rash

Edema of face



Loss of appetite

Upset stomach



DryKid Training works in about 90 days for most kids, even when parents have tried all the other things INCLUDING restricting liquids, waking at night, or an alarm! Learn the rules you need to follow and the procedures you can do at home with your child to start seeing results in the first two weeks of training!

Order your download of the video training here.

Underdeveloped Bladder? Seriously?

Another excuse for not doing anything about bedwetting has become popular in recent years.

“Your child’s bladder is underdeveloped and that’s why he wets the bed. Just restrict liquids and wait until he outgrows it.”


(click on word if you need the definition)

The bladder is a muscle and just like any muscle, it needs excercise. If it doesn’t get used it gets smaller and weaker. But you can’t take your child’s bladder to the gym so what do you d0? Start drinking! (not alcohol – water.)

Everybody knows that water is good for you and everybody says you need it to survive. Well, you know how the bladder stores urine? Well, if you restrict liquids it can’t do that. Storing urine is like taking the bladder to the gym. Using it to store urine will stretch the muscular walls of the bladder, thus making is stronger and more able to hold urine, even at night. This is one of the concepts that DryKid Training uses to get most kids dry in about 90 days. It’s just that simple.

Bedwetting Schmedwetting – Out do it. Not outgrow it.

The more I see what’s still out there about bedwetting the more disappointed I become. I’ve helped hundreds of families out-do bedwetting in their children. Is it possible that we still really believe that restricting liquids has anything at all to do with bedwetting? Doctors, why are you still advising your parents to “wait until (s)he outgrows it!” Waiting doesn’t cure bedwetting. Restricting liquids doesn’t cure bedwetting. Medication doesn’t even cure bedwetting. What does? Training. It’s that simple. There are a few rules and a few tools to use but it can be done! (Yes, with a bedwetting alarm – but watch the video to learn what type).

It takes a little time to out-do bedwetting. It doesn’t go away overnight. The quickest I’ve seen a kid get dry was 2 weeks. But the norm is more like 90 days (3 months). Some kids take a little longer, too. But that’s okay. If it goes longer than average, we should also look at other potential causes (e.g. food allergy). But the bottom line is, DO SOMETHING about bedwetting. The longer it continues the greater the likelihood of the ‘secret’ getting out.

A short post today because I spent the majority of the day working on the video. I hope you like it.



Is bedwetting inherited?

Bedwetting is kind of inherited, but not exactly.

Sometimes a kid that wets the bed has a parent or grandparent that also wet the bed but since bedwetting (which is also called enuresis [en-your-ee-sis]) is a sleep disorder, it’s more common to see other sleep disorders such as snoring, sleep apnea and narcolepsy. It’s nice to know the cause of bedwetting because bedwetting can be caused by a medical condition. However, this is rare. A clue that bedwetting may be due to a medical condition is that there is a period of waking up dry (e.g. several months) before the bedwetting began again.

To read more about sleep disorders click here.